英国正版365官方网站 有机电子与信息显示国家重点实验室
beat365手机中文官方教师,教授,硕士生导师
联系方式:
办公地点: 英国正版365官方网站仙林校区学科楼401
Email: lguo@njupt.edu.cn
个人主要简历:
2015/8-至今,英国正版365官方网站,beat365手机中文官方,教授
2017/11-2018/11,美国MD安德森癌症中心,访问学者
2011/9-2015/7,南京医科大学,公共卫生学院,讲师
2009/2-2011/9,东南大学,生物医学工程,工学博士
2003/9-2006/6,南京师范大学,生物化学与分子生物学,理学硕士
研究领域:
生物信息学;生物医学信息学;系统生物学;进化医学
主要科研项目:
1. 国家自然科学基金面上项目,62171236,2022.01-2025.12,64万,在研,主持;
2. 国家自然科学基金面上项目,61771251,2018.01-2021.12,62万,结题,主持;
3. 国家自然科学基金青年基金项目,61301251,2014.1-2016.12,28万元,结题,主持;
4. 江苏省重点研发计划(社会发展)-面上项目,BE2022799,2022.07-2025.06,100万元,在研,主持;
5. 江苏省重点研发计划(社会发展)-面上项目,BE2016773,2016.07-2019.06,80万元,结题,主持;
6. 江苏省自然科学基金面上项目,BK20171443,2017.07-2020.07,10万元,结题,主持;
7. 江苏省自然科学基金青年基金项目,BK20130885,2013.07-2016.07,20万元,结题,主持;
8. 教育部博士学科点基金(新教师基金),20133234120009,2014.01-2016.12,4万元,结题,主持;
9. 江苏省高校自然科学基金,13KJB330003,2013.08-2015.12,3.2万元,结题,主持;
10. 国家级重点实验室课题,2022.01-2024.12,3万元,在研,主持。
主要学术成绩/奖励荣誉:
江苏省青蓝工程优秀青年骨干教师培养对象,长期从事生物医学信息学及系统生物学相关研究,具体包括:(1)整合多组学数据研究复杂疾病发生发展过程的转录调控机制;(2)ncRNA在复杂疾病中的cross-talk及调控规律挖掘;(3)基于合成致死策略的潜在药物靶点研究。近5年来,以第一/通讯作者身份在Briefings in Bioinformatics、Genes & Diseases、Journal of Lipid Research、Computational and Structural Biotechnology Journal及FEBS Journal等期刊发表30多篇SCI论文,授权专利3项。
10篇代表性学术论文:
1. Guo L, Li Y, Cirillo KM, et al. mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity.Briefings in Bioinformatics, 2021, 22(5): bbab091.
2. Guo L, Liang T. MicroRNAs and their variants in an RNA world: implications for complex interactions and diverse roles in an RNA regulatory network. Briefings in Bioinformatics, 2018, 19(2): 245-253.
3. Liang T, Jia L… Guo L*. Inhibition of ALDH2 by disulfiram leads to synthetic lethality via ROS strikes twice in ARID1A-deficient cholangiocarcinoma. Genes & Diseases, 2022, DOI: 10.1016/j.gendis.2022.02.005.
4. Ma M, Duan R…Guo L*. The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice. Journal of Lipid Research, 2020, 61(7): jlr.RA120000664.
5. Guo L, Li S, Yan X, et al. A comprehensive multi-omics analysis reveals molecular features associated with cancer via RNA cross-talks in the Notch signaling pathway. Computational and Structural Biotechnology Journal, 2022, 20, 3972-3985.
6. Guo L, Li S, Qian B, et al. Integrative omics analysis reveals relationships of genes with synthetic lethal interactions through a pan-cancer analysis. Computational and Structural Biotechnology Journal, 2020, 18, 3243-3254.
7. Guo L, Dou Y, Xiang Y, et al. Systematic analysis of cancer-specific synthetic lethal interactions provides insight into personalized anticancer therapy. FEBS Journal, 2022, 10.1111/febs.16643.
8. Du Y, Luo L…Guo L*. Unleashing the Power of Synthetic Lethality: Augmenting Treatment Efficacy through Synergistic Integration with Chemotherapy Drugs.Pharmaceutics, 2023, 15, 2433.
9. Guo L, Dou Y, Xia D, et al. SLOAD: a comprehensive database of cancer-specific synthetic lethal interactions for precision cancer therapy via multi-omics analysis. Database: the journal of biological databases and curation, 2022, baac075.
10. Ma M, Yin Z…Guo L*. Analysis of the expression, function, and evolution of miR-27 isoforms and their responses in metabolic processes. Genomics, 2019, 111(6), 1249-1257.